Born in Chile, Estefania Miranda was awarded a scholarship at the age of 15 and studied dance in Edinburgh, Scotland, and at the Tilburg University of the Arts in the Netherlands. In her third year of study, she became a soloist of the Ismael Ivo company at the Deutsches Nationaltheater Weimar in Germany. Ismael Ivo, the enfant terrible of international dance, co-founder of the Impuls Dance Festival Vienna and director of the Venice/Dance Biennial, created outstanding roles for her, including Medea in Medeamaterial after Heiner Müller. The productions Der nackte Michelangelo, directed by the great George Tabori at the Schaubühne in Berlin, and Auswanderungen, based on a joint idea by Ivo and Heiner Müller about Antonin Artaud, attracted particular attention. International tours followed. During this period, Estefania Miranda developed her first choreographies for the Deutsches Nationaltheater Weimar and taught at the Hochschule der Künste Leipzig from 1998 to 2001. In 2000, director Susanne Lietzow discovered her as an actress and integrated her into the company of actors at the Deutsches Nationaltheater Weimar. A long-standing collaboration developed, during which she played several leading roles, including Marie in Woyzeck. From 2003, she worked on a series of projects as a dancer and actress, including at the Schauspiel Hannover, the Theater Phönix Linz, with Marina Abramovic in Paris and Hans van den Broeck, co-founder of Les Ballets C de la B, in Vienna.

In 2009, she founded the Company Estefania Miranda and acquired her own production centre with a stage and café in Berlin. Alongside her work as a choreographer, in 2010 she was appointed curator of dance at the Deutsches Nationaltheater Weimar and director of the Weimar International Dance Festival, which she founded.

In 2013, Estefania Miranda was appointed Director of Bern Ballet. Under her directorship and curation, consistently sold-out performances and high praise from the press quickly made Bern Ballet, the most successful branch of the theatre and best selling dance company in Switzerland. Her immersive choreographies Vier Jahreszeiten and La Divina Comedia, which dissolve the boundaries between stage and audience, have been particularly popular. Under her direction, the ensemble toured China and a new rehearsal building was acquired.  The ensemble was also awarded the Prix Suisse De La Danse for current choreographic creation in 2015 and the Prix Pro Senectute for work with senior citizens in 2019. She is the founder of the Tanzplattform Bern festival, and set up comprehensive medical care for the ensemble's members, as well as the first recalcification fund for a Swiss dance company. At the end of 2021, Estefania Miranda stepped down for health reasons and continued to work for Bern Ballett from spring 2022 as curating consultant for the 2023/24 and 2024/25 seasons. In 2023, she founded a dance project in Costa Rica to study the dance rituals of the Maleku indigenous tribe and developed a dance project in Nicosia, Cyprus, the world's last divided capital. In her multidisciplinary and immersive work, she creates visually rich productions that break with theatrical conventions and ask critical questions about colonialism, racism and environmental destruction.